Article
A burning question from the first international BPAN symposium: is restoration of autophagy a promising therapeutic strategy for BPAN?
Autophagy - 1 Dec 2023
Mollereau Bertrand, Hayflick Susan J, Escalante Ricardo, Mauthe Mario, Papandreou Apostolos, Iuso Arcangela, Celle Marion, Aniorte Sahra, Issa Abdul Raouf, Lasserre Jean Paul, Lesca Gaetan, Thobois Stéphane, Burger Pauline, Walter Ludivine
Abstract excerpt
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare neurodegenerative disease associated with severe cognitive and motor deficits. BPAN pathophysiology and phenotypic spectrum are still emerging due to the fact that mutations in the WDR45 (WD repeat domain 45) gene, a regulator of macroautophagy/autophagy, were only identified a decade ago. In the first international symposium dedicated to BPAN,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.