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Article

Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis.

Nature cell biology - 1 Apr 2024

Zhu Ye, Fujimaki Motoki, Snape Louisa, Lopez Ana, Fleming Angeleen, Rubinsztein David C

Abstract excerpt

β-Propeller protein-associated neurodegeneration (BPAN) is a rare X-linked dominant disease, one of several conditions that manifest with neurodegeneration and brain iron accumulation. Mutations in the WD repeat domain 45 (WDR45) gene encoding WIPI4 lead to loss of function in BPAN but the cellular mechanisms of how these trigger pathology are unclear. The prevailing view in the literature is that BPAN is simply...

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PMID: 38454050
DOI: 10.1038/s41556-024-01373-3
PMCID: PMC11021183

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