Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression.

Translational psychiatry - 12 Jul 2016

Meylan E M, Breuillaud L, Seredenina T, Magistretti P J, Halfon O, Luthi-Carter R, Cardinaux J-R

Abstract excerpt

Recent studies implicate the arginine-decarboxylation product agmatine in mood regulation. Agmatine has antidepressant properties in rodent models of depression, and agmatinase (Agmat), the agmatine-degrading enzyme, is upregulated in the brains of mood disorder patients. We have previously shown that mice lacking CREB-regulated transcription coactivator 1 (CRTC1) associate behavioral and molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Cerebral Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder

Share to Eukaryotic Initiation Factor-2

Share to Excitatory Amino Acid Antagonists

Share to Interneurons

Share to Microarray Analysis

Share to Prefrontal Cortex

Source

Open in PubMed Open full text

Identifiers

PMID: 27404284
DOI: 10.1038/tp.2016.116
PMCID: PMC5545706

Genes

BDNF
CRTC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression.PMID 27404284Read ↗

A suite of engineered mice for interrogating psychedelic drug actionsSemantic proximity Read ↗

Gene expression profile associated with Asmt knockout-induced depression-like behaviors and exercise effects in mouse hypothalamusSemantic proximity Read ↗

C12ORF57: a novel principal regulator of synaptic AMPA currents and excitatory neuronal homeostasisSemantic proximity Read ↗

Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8).Semantic proximity Read ↗

Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.Semantic proximity Read ↗

Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice.Semantic proximity Read ↗

Chronic stress and impaired glutamate function elicit a depressive-like phenotype and common changes in gene expression in the mouse frontal cortex.Semantic proximity Read ↗

Riluzole Restores Circuit and Behavioral Function Altered by Allele-Specific Expression-Mediated LINC02449-CPLX1 Dysregulation.Semantic proximity Read ↗

Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction.Semantic proximity Read ↗

Expression Profiling of a Genetic Animal Model of Depression Reveals Novel Molecular Pathways Underlying Depressive-Like BehavioursSemantic proximity Read ↗

Dnmt1-deficiency in PV interneurons alters cortical circuit function and leads to depression-like behaviorSemantic proximity Read ↗

Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.