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Article

Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.

BMC medicine - 14 Jul 2023

Yin Mei-Yu, Guo Lei, Zhao Li-Juan, Zhang Chen, Liu Wei-Peng, Zhang Chu-Yi, Huo Jin-Hua, Wang Lu, Li Shi-Wu, Zheng Chang-Bo, Xiao Xiao, Li Ming, Wang Chuang, Chang Hong

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but the regulation effect of the risk SNPs on VRK2 as well as their roles in the illness are yet to be elucidated. METHODS: Based on the summary statistics of major depression GWAS, we conducted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37452335
DOI: 10.1186/s12916-023-02945-0
PMCID: PMC10349461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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