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Beyond viability: Advancing CHO cell culture process strategies to modulate host cell protein levels

30 Oct 2024

Abstract excerpt

Chinese Hamster Ovary (CHO) cells are widely utilized in bioprocessing industry for monoclonal antibody (mAb) production. In many instances, challenges persist in achieving sufficient clearance of Host Cell Proteins (HCPs) in the final drug substance. While purification strategies usually offer substantial HCP clearance, certain "problematic" HCPs, particularly lipases, continue to pose significant challenges....

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PMID: 39481535
DOI: 10.1016/j.nbt.2024.10.003

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