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Article

Comparison of Bcl-2 to a Bcl-2 deletion mutant for mammalian cells exposed to culture insults.

Biotechnology and bioengineering - 5 May 2001

Figueroa B, Sauerwald T M, Mastrangelo A J, Hardwick J M, Betenbaugh M J

Abstract excerpt

Apoptosis has been found to occur in bioreactors as a result of environmental stresses. The overexpression of bcl-2 is a widely used strategy to limit the induction of apoptosis in mammalian cell cultures. In this study, the effectiveness of wild-type Bcl-2 was compared to a Bcl-2 mutant lacking the nonstructured loop domain in two commercially prominent cell lines, Chinese hamster ovary (CHO) and baby hamster...

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Identifiers

PMID: 11257603
DOI: 10.1002/bit.1053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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