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Article

TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma.

Journal of translational medicine - 1 Dec 2023

Zhou Yiran, Jin Jiabin, Ji Yuchen, Zhang Jiaqiang, Fu Ningzhen, Chen Mengmin, Wang Jun, Qin Kai, Jiang Yu, Cheng Dongfeng, Deng Xiaxing, Shen Baiyong

Abstract excerpt

BACKGROUND: Although the molecular features of pancreatic ductal adenocarcinoma (PDAC) have been well described, the impact of detailed gene mutation subtypes on disease progression remained unclear. This study aimed to evaluate the impact of different TP53 mutation subtypes on clinical characteristics and outcomes of patients with PDAC. METHODS: We included 639 patients treated with PDAC in Ruijin Hospital...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38037073
DOI: 10.1186/s12967-023-04742-y
PMCID: PMC10691048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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