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TP53 Gain-of-Function and Non-Gain-of-Function Mutations Are Associated With Differential Prognosis in Advanced Pancreatic Ductal Adenocarcinoma.

JCO precision oncology - 1 May 2023

Pan Minggui, Jiang Chen, Zhang Zheyang, Achacoso Ninah, Alexeeff Stacey, Solorzano Aleyda V, Tse Pam, Chung Elaine, Sundaresan Tilak, Suga Jennifer Marie, Thomas Sachdev, Habel Laurel A

Abstract excerpt

PURPOSE: To examine the impact of TP53 gain-of-function (GOF) and non-GOF mutations on prognosis of advanced pancreatic ductal adenocarcinoma (PDAC) among patients with KRAS, CDKN2A, and SMAD4 comutations. METHODS: This cohort included patients with locally advanced, recurrent, and de novo metastatic PDAC with next-generation sequencing performed from November 2017 to May 2022. We defined R175H, R248W, R248Q,...

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PMID: 37163715
DOI: 10.1200/PO.22.00570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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