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Article

Prognostic Properties of KRAS Gene Mutation Subtypes in Resected Pancreatic Ductal Adenocarcinoma.

Pancreas - 1 May 2025

Nusrat Faria, Gorgov Eliyahu, Khanna Akshay, Isesele Obehioye, Bowne Wilbur, Lavu Harish, Yeo Charles J, Jiang Wei, Jain Aditi, Nevler Avinoam

Abstract excerpt

INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) has a distinct genomic profile, with somatic KRAS mutations occurring in 85%-95% of all PDAC cases. This study aimed to measure the prognostic impact of specific KRAS mutations in resected PDAC patients from a large, high-volume center. METHODS: This retrospective study included a cohort of PDAC patients who underwent curative-intent pancreatic resection at...

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Biomarkers, Tumor
Carcinoma, Pancreatic Ductal
High-Throughput Nucleotide Sequencing
Kaplan-Meier Estimate
Pancreatectomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 40314742
DOI: 10.1097/MPA.0000000000002458

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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