Article
HLA-DR genetic polymorphisms and hepatitis B virus mutations affect the risk of hepatocellular carcinoma in Han Chinese population.
Virology journal - 30 Nov 2023
Zhao Yubao, Chen Kun, Yang Hui, Zhang Feng, Ding Lu, Liu Yan, Zhang Le, Zhang Yuchen, Wang Huiliang, Deng Yang
Abstract excerpt
BACKGROUND: Human leucocyte antigen (HLA)-DR plays a crucial role in the immune response against hepatitis B virus (HBV). We aimed to investigate the associations of HLA-DR single nucleotide polymorphisms (SNPs) with the generation of hepatocellular carcinoma (HCC)-related HBV mutations. The effects of HLA-DR SNPs and their interactions with HBV mutations on HCC risks were also determined. METHODS: Five HLA-DR...
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