Article
HLA-DR genetic polymorphisms and hepatitis B virus mutations affect the risk of hepatocellular carcinoma in Han Chinese population.
Virology journal - 30 Nov 2023
Zhao Yubao, Chen Kun, Yang Hui, Zhang Feng, Ding Lu, Liu Yan, Zhang Le, Zhang Yuchen, Wang Huiliang, Deng Yang
Abstract excerpt
BACKGROUND: Human leucocyte antigen (HLA)-DR plays a crucial role in the immune response against hepatitis B virus (HBV). We aimed to investigate the associations of HLA-DR single nucleotide polymorphisms (SNPs) with the generation of hepatocellular carcinoma (HCC)-related HBV mutations. The effe...
Topics
- Humans
- Carcinoma, Hepatocellular
- East Asian People
- Genetic Predisposition to Disease
- Genotype
- Hepatitis B virus
- Hepatitis B, Chronic
- HLA-DR Antigens
- Liver Neoplasms
- Mutation
- Polymorphism, Single Nucleotide