Article
Hepatitis B virus genotype, mutations, human leukocyte antigen polymorphisms and their interactions in hepatocellular carcinoma: a multi-centre case-control study.
Scientific reports - 16 Nov 2015
Wen Juan, Song Ci, Jiang Deke, Jin Tianbo, Dai Juncheng, Zhu Liguo, An Jiaze, Liu Yao, Ma Shijie, Qin Na, Liang Cheng, Chen Jiaping, Jiang Yue, Yang Linlin, Liu Jibin, Liu Li, Geng Tingting, Chen Chao, Jiang Jie, Chen Jianguo, Zhu Fengcai, Zhu Yefei, Yu Long, Shen Hongbing, Zhai Xiangjun, Xu Jianfeng, Hu Zhibin
Abstract excerpt
Three genome-wide association studies (GWAS) have been conducted on the genetic susceptibility of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), two of which consistently identified tagging single nucleotide polymorphisms (SNPs) around HLA-DQ/DR. In contrast, large multi-centre association studies between HBV genotype, mutations and the risk of HCC are relatively rare, and their interactions with...
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