Article
Genetic susceptibility of eight nonsynonymous polymorphisms in HLA-DRB1 gene to hepatocellular carcinoma in Han Chinese.
Oncotarget - 6 Dec 2016
Shi Yanhui, Zhai Weiyu, Wang Bin, Zhao Dongmei, Jin He, Wang Yuefei, Zhang Jidong, An Hongjun, Fu Zhongze, Zhao Kun, Lu Changzhu
Abstract excerpt
Backgrounds and Objective: Mounting evidence suggests that human leukocyte antigen (HLA) plays a central role in anti-virus and tumor defense. To test whether genetic variation in HLA-DRB1 gene, a key component of HLA system, can predict its predisposition to hepatocellular carcinoma (HCC), we thereby conducted an association study by genotyping 8 nonsynonymous polymorphisms in HLA-DRB1 gene among 257 HCC...
Topics
- Aged
- Asian People
- Biomarkers, Tumor
- Carcinoma, Hepatocellular
- Case-Control Studies
- Chi-Square Distribution
- China
- Exons
- Female
- Gene Frequency
- Genetic Association Studies