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Article

Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine A3 receptor.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2021

Stoddart Leigh A, Kilpatrick Laura E, Corriden Ross, Kellam Barrie, Briddon Stephen J, Hill Stephen J

Abstract excerpt

Organization of G protein-coupled receptors at the plasma membrane has been the focus of much recent attention. Advanced microscopy techniques have shown that these receptors can be localized to discrete microdomains and reorganization upon ligand activation is crucial in orchestrating their signaling. Here, we have compared the membrane organization and downstream signaling of a mutant (R108A, R3.50A) of the...

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PMID: 33710641
DOI: 10.1096/fj.202001729RR
PMCID: PMC9328438

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