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Article

Mechanism of co-operation of mutant IL-7Rα and mutant NRAS in acute lymphoblastic leukemia: role of MYC.

Haematologica - 1 Jun 2024

Winer Hila, Li Wenqing, Rodrigues Gisele, Gower Tim, Meyer Thomas Joshua, Hixon Julie, Durum Scott K

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is an aggressive leukemia which can be derived from either T-cell or B-cell precursors. With current treatments, the survival rate is high, but the treatments are highly toxic with severe side effects. Individual mutations in IL7Ra and RAS pathways have been previously shown to be prevalent in ALL, and especially in relapsed patients. The relationship of IL-7Ra and RAS was...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Monomeric GTP-Binding Proteins

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-myc

Share to Receptors, Interleukin-7

Source

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Identifiers

PMID: 38031763
DOI: 10.3324/haematol.2023.283559
PMCID: PMC11141644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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