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Article

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment

7 Jun 2016

Abstract excerpt

Increased understanding of pediatric acute lymphoblastic leukemia (ALL) pathobiology has led to dramatic improvements in patient survival. However, there is still a need to develop targeted therapies to enable reduced chemotherapy intensity and to treat relapsed patients. The interleukin-7 receptor α (IL-7Rα) signaling pathways are prime therapeutic targets because these pathways harbor genetic aberrations in...

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PMID: 27268088
DOI: 10.1182/blood-2016-03-679209

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