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Article

Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics.

Cellular immunology - 1 Feb 2021

Becerra-Díaz Mireya, Lerner Andrew D, Yu Diana H, Thiboutot Jeffrey P, Liu Mark C, Yarmus Lonny B, Bose Sonali, Heller Nicola M

Abstract excerpt

Allergic asthma affects more women than men. It is mediated partially by IL-4/IL-13-driven polarization of monocyte-derived macrophages in the lung. We tested whether sex differences in asthma are due to differential IL-4 responsiveness and/or chemokine receptor expression in monocytes and monocyte-derived macrophages from healthy and allergic asthmatic men and women. We found female cells expressed M2 genes more...

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Identifiers

PMID: 33450610
DOI: 10.1016/j.cellimm.2020.104252
PMCID: PMC9109226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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