Article
FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype.
Oncotarget - 5 Apr 2016
Chung Sangwoon, Lee Tae Jin, Reader Brenda F, Kim Ji Young, Lee Yong Gyu, Park Gye Young, Karpurapu Manjula, Ballinger Megan N, Qian Feng, Rusu Luiza, Chung Hae Young, Unterman Terry G, Croce Carlo M, Christman John W
Abstract excerpt
Inflammatory monocyte and tissue macrophages influence the initiation, progression, and resolution of type 2 immune responses, and alveolar macrophages are the most prevalent immune-effector cells in the lung. While we were characterizing the M1- or M2-like macrophages in type 2 allergic inflammation, we discovered that FoxO1 is highly expressed in alternatively activated macrophages. Although several studies...
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