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Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation

1 Dec 2024

Abstract excerpt

Neutrophils are the most abundant cell type in the airways of tuberculosis patients. Mycobacterium tuberculosis ( Mtb ) infection induces the release of neutrophil extracellular traps (NETs); however, the molecular regulation and impact of NET release on Mtb pathogenesis are unknown. We find that during Mtb infection in neutrophils, PAD4 citrullinates histones to decondense chromatin that gets released as NETs in...

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PMID: 39637864
DOI: 10.1016/j.chom.2024.11.008

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