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Article

Quaking isoforms cooperate to promote the mesenchymal phenotype.

Molecular biology of the cell - 1 Feb 2024

Neumann Daniel P, Phillips Caroline A, Lumb Rachael, Palethorpe Helen M, Ramani Yesha, Hollier Brett G, Selth Luke A, Bracken Cameron P, Goodall Gregory J, Gregory Philip A

Abstract excerpt

The RNA-binding protein Quaking (QKI) has widespread effects on mRNA regulation including alternative splicing, stability, translation, and localization of target mRNAs. Recently, QKI was found to be induced during epithelial-mesenchymal transition (EMT), where it promotes a mesenchymal alternative splicing signature that contributes to the mesenchymal phenotype. QKI is itself alternatively spliced to produce...

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Identifiers

PMID: 38019605
DOI: 10.1091/mbc.E23-08-0316
PMCID: PMC10881146

Genes

QKI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Quaking isoforms cooperate to promote the mesenchymal phenotype.PMID 38019605Read ↗

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