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Article

QKI deficiency maintains glioma stem cell stemness by activating the SHH/GLI1 signaling pathway.

Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2019

Han Bo, Wang Ruijia, Chen Yongjie, Meng Xiangqi, Wu Pengfei, Li Ziwei, Duan Chunbin, Li Qingbin, Li Yang, Zhao Shihong, Jiang Chuanlu, Cai Jinquan

Abstract excerpt

PURPOSE: Glioblastoma (GBM) stem cells (GSCs) have been found to be the main cause of malignant GBM progression. It has also been found that Quaking homolog (QKI) plays a predominant role in driving GBM development. Here, we aimed to asses the role of QKI in maintaining GSC stemness and inducing the invasiveness of GBM cells. METHODS: Public databases were used to assess the expression of QKI and its correlation...

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Source

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Identifiers

PMID: 31292920
DOI: 10.1007/s13402-019-00463-x
PMCID: PMC12994293

Genes

QKI
GLI1
GSC
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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