Article
A global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation.
Genome biology - 14 Oct 2021
Ren Yue, Huo Yue, Li Weiqian, He Manman, Liu Siqi, Yang Jiabin, Zhao Hongmei, Xu Lingjie, Guo Yuehong, Si Yanmin, Zhao Hualu, Rao Shuan, Wang Jing, Ma Yanni, Wang Xiaoshuang, Yu Jia, Wang Fang
Abstract excerpt
BACKGROUND: Cellular RNA-binding proteins (RBPs) have multiple roles in post-transcriptional control, and some are shown to bind DNA. However, the global localization and the general chromatin-binding ability of RBPs are not well-characterized and remain undefined in hematopoietic cells. RESULTS: We first provide a full view of RBPs' distribution pattern in the nucleus and screen for chromatin-enriched RBPs...
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