Article

Epithelial QKI Protects Against Emphysema by Maintaining Mitochondrial Integrity

2026-07-10

Abstract excerpt

Single-cell transcriptomic profiling of chronic obstructive pulmonary disease (COPD) lungs identified QKI, an RNA-binding protein, as a candidate emphysema-associated gene, but its epithelial role in COPD pathobiology remains unclear. We show that QKI expression is reduced in human COPD lungs and that alveolar type 2 epithelial (AT2) cell QKI protein levels correlate strongly with spirometric indices and diffusing...

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Literature Corpus work: 611496f4-3340-5459-895d-91e9eec2c5b9
DOI: 10.64898/2026.07.09.737340

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