Article
Post-transcriptional repression of FOXO1 by QKI results in low levels of FOXO1 expression in breast cancer cells
31 Dec 2013
Abstract excerpt
The RNA-binding protein Quaking (QKI) is known to be essential for embryonic development and postnatal myelination. Forkhead box O1 (FOXO1) is a critical tumor suppressor for cell proliferation control. Dysregulation of FOXO1 expression has been observed in a variety of cancers. In the present study, we demonstrated that QKI decreased FOXO1 mRNA expression at the post-transcriptional level. QKI was able to bind...
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