Article
Programmable base editing of mutated TERT promoter inhibits brain tumour growth.
Nature cell biology - 1 Mar 2020
Li Xinjian, Qian Xu, Wang Bin, Xia Yan, Zheng Yanhua, Du Linyong, Xu Daqian, Xing Dongming, DePinho Ronald A, Lu Zhimin
Abstract excerpt
Clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR interference and programmable base editing have transformed the manipulation of eukaryotic genomes for potential therapeutic applications1-4. Here, we exploited CRISPR interference and programmable base editing to determine their potential in editing a TERT gene promoter-activating mutation, which occurs in many diverse cancer types,...
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