Article

Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

2026-02-06

Abstract excerpt

<h4>Background and Aims</h4> Novel antiviral approaches capable of permanently inactivating the intrahepatic HBV DNA reservoir, the covalently closed circular DNA (cccDNA) and HBV DNA integrated into the host genome, are urgently needed. This study evaluated adenine base editing as a strategy to disrupt HBV replication by introducing mutations in the overlapping HBs/polymerase open reading frame (ORF). <h4>Method...

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Literature Corpus work: d19c4549-65d7-5488-a032-a4340f1e2b80
DOI: 10.64898/2026.02.06.704371

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