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Cytosine base editing inhibits hepatitis B virus replication and reduces HBsAg expression in vitro and in vivo

27 Dec 2023

Abstract excerpt

Chronic hepatitis B virus (HBV) infection remains a global health problem due to the lack of treatments that prevent viral rebound from HBV covalently closed circular (ccc)DNA. In addition, HBV DNA integrates in the human genome, serving as a source of hepatitis B surface antigen (HBsAg) expression, which impairs anti-HBV immune responses. Cytosine base editors (CBEs) enable precise conversion of a cytosine into...

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PMID: 38292874
DOI: 10.1016/j.omtn.2023.102112

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