SLC26A3 (DRA, the Congenital Chloride Diarrhea Gene): A Novel Therapeutic Target for Diarrheal Diseases.

doi:10.1016/j.jcmgh.2024.101452

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Article

SLC26A3 (DRA, the Congenital Chloride Diarrhea Gene): A Novel Therapeutic Target for Diarrheal Diseases.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2025

Kumar Anoop, Jayawardena Dulari, Priyamvada Shubha, Anbazhagan Arivarasu N, Chatterjee Ishita, Saksena Seema, Dudeja Pradeep K

Abstract excerpt

Diarrhea associated with enteric infections, gut inflammation, and genetic defects poses a major health burden and results in significant morbidity and mortality. Impaired fluid and electrolyte absorption or secretion in the intestine are the hallmark of diarrhea. Electroneutral NaCl absorption in the mammalian GI tract involves the coupling of Na+/H+ and Cl-/HCO3- exchangers. SLC26A3 (Down Regulated in Adenoma,...

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Topics

Humans
Animals
Diarrhea
Sulfate Transporters
Chloride-Bicarbonate Antiporters
Metabolism, Inborn Errors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Intestinal Mucosa

Antiporters

Molecular Targeted Therapy

Mice

Disease Models, Animal

Inflammatory Bowel Diseases

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39736385
DOI: 10.1016/j.jcmgh.2024.101452
PMCID: PMC12003007

Genes

SLC26A3

Provenance

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