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Article

Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination.

Gut - 1 Oct 2021

Sundar Raghav, Liu Drolaiz Hw, Hutchins Gordon Ga, Slaney Hayley L, Silva Arnaldo Ns, Oosting Jan, Hayden Jeremy D, Hewitt Lindsay C, Ng Cedric Cy, Mangalvedhekar Amrita, Ng Sarah B, Tan Iain Bh, Tan Patrick, Grabsch Heike I

Abstract excerpt

OBJECTIVE: Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis (LNmet). DESIGN: GC resection samples were annotated to identify primary tumour superficial (PTsup), primary tumour deep...

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Identifiers

PMID: 33229445
DOI: 10.1136/gutjnl-2020-320805
PMCID: PMC8458060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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