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Article

A-296G variant of THBS1 gene (rs1478605) is associated with a lower frequency of stroke in a Brazilian population with sickle cell anemia.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2024

Oliveira Jessica M F, Arcanjo Gabriela S, Domingos Igor F, Batista Jéssica V G F, Pereira-Martins Diego A, Batista Thais H C, Hatzlhofer Betânia L D, Falcão Diego A, Diniz Madi V, Silva Alexsandro P, Pires Bárbara C V, Dos Anjos Ana C, Costa Fernando F, Araujo Aderson S, Lucena-Araujo Antonio R, Bezerra Marcos A

Abstract excerpt

OBJECTIVES: Stroke is a devastating clinical outcome that significantly contributes to the morbidity and mortality of sickle cell anemia (SCA) patients. Despite its advantages in predicting stroke risk, transcranial Doppler screening has limitations that restrict its applicability, highlighting the need for emerging prognostic tools. Thrombospondin-1 plays a crucial role in endothelial injury, platelet adhesion,...

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Identifiers

PMID: 38006767
DOI: 10.1016/j.jstrokecerebrovasdis.2023.107474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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