Article
Influence of the βs haplotype and α-thalassemia on stroke development in a Brazilian population with sickle cell anaemia.
Annals of hematology - 1 Jul 2014
Domingos Igor F, Falcão Diego A, Hatzlhofer Betania L, Cunha Anderson F, Santos Magnun N, Albuquerque Dulcinéia M, Fertrin Kleber Y, Costa Fernando F, Azevedo Renata C, Machado Cíntia G, Araújo Aderson S, Lucena-Araujo Antonio R, Bezerra Marcos A
Abstract excerpt
Stroke is a catastrophic complication of sickle cell anaemia (SCA) and is one of the leading causes of death in both adults and children with SCA. Evidence suggests that some genetic polymorphisms could be related to stroke development, but their association remains controversial. Here, we performed genotyping of five published single nucleotide polymorphisms, the α-thalassemia genotype, the G6PD A (-) variant...
Topics
- Adolescent
- Adult
- Anemia, Sickle Cell
- Brazil
- Child
- Child, Preschool
- Cohort Studies
- Female
- Haplotypes
- Humans
- Infant
- Male
- Polymorphism, Single Nucleotide