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Article

Influence of Haptoglobin Polymorphism on Stroke in Sickle Cell Disease Patients

14 Jan 2022

Abstract excerpt

This review outlines the current clinical research investigating how the haptoglobin (Hp) genetic polymorphism and stroke occurrence are implicated in sickle cell disease (SCD) pathophysiology. Hp is a blood serum glycoprotein responsible for binding and removing toxic free hemoglobin from the vasculature. The role of Hp in patients with SCD is critical in combating blood toxicity, inflammation, oxidative stress,...

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PMID: 35052484
DOI: 10.3390/genes13010144

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