Genetic Modifiers of Stroke in Patients with Sickle Cell Disease-A Scoping Review.

Abstract excerpt

Sickle cell disease (SCD) clinically manifests itself with a myriad of complications. Stroke, both ischemic and hemorrhagic, as well as silent white matter changes, occurs at a relatively high prevalence. Understanding why and in whom stroke is most likely to occur is critical to the effective prevention and treatment of individuals with SCD. Genetic studies, including genome- and exome-wide association studies...

Topics

• Humans
• Anemia, Sickle Cell
• Stroke
• Genome-Wide Association Study
• Genetic Predisposition to Disease
• Genes, Modifier
• Fetal Hemoglobin