Article
Polymorphisms and gene expression of metalloproteinases and their inhibitors associated with cerebral ischemic stroke in young patients with sickle cell anemia.
Molecular biology reports - 1 Apr 2023
do Kleyton Palmeira Ó, da Silva Freire Ana Karla, de Nóbrega Débora Nascimento, Dos Santos Souza Roberta, Farias Isabela Cristina Cordeiro, de Mendonça Belmont Taciana Furtado, da Silva Andreia Soares, da Silva Arcanjo Gabriela, da Silva Araujo Aderson, Dos Anjos Ana Cláudia Mendonça, de Araujo Antônio Roberto Lucena, Bezerra Marcos André Cavalcanti, de Moura Patricia Muniz Mendes Freire, do Socorro Mendonça Cavalcanti Maria, Vasconcelos Luydson Richardson Silva
Abstract excerpt
BACKGROUND: Sickle cell anemia (SCA) is a genetic disease with great clinical heterogeneity and few viable strategies for treatment; hydroxyurea (HU) is the only widely used drug. Thus, the study of single nucleotide polymorphisms (SNPs) and the gene expression of MMPs 1, 2, 9, 7 and TIMPs 1 and 2, which are involved in the regulation of extracellular matrix, inflammation, and neuropathies, may provide further...
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