Article

Advanced simulations and screening to design a 3C protease inhibitor against the drug resistant human norovirus-induced gastroenteritis

2022-04-27

Abstract excerpt

Human norovirus (HuNoV) causes acute viral gastroenteritis in all age groups, and dehydration and severe diarrhea in the elderly. The World Health Organization reports ~ 1.45 million deaths from acute gastroenteritis annually in the world. Rupintrivir, an inhibitory medicine against the human rhinovirus C3 protease, has been reported to inhibit HuNoV 3C protease. However, several HuNoV 3C protease mutations have b...

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Literature Corpus work: 81bb5ed2-3be5-5b77-afb7-7daa7efa5767
DOI: 10.21203/rs.3.rs-1591559/v1

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