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Article

Nonnucleoside inhibitors of norovirus RNA polymerase: scaffolds for rational drug design.

Antimicrobial agents and chemotherapy - 1 Jun 2014

Eltahla Auda A, Lim Kun Lee, Eden John-Sebastian, Kelly Andrew G, Mackenzie Jason M, White Peter A

Abstract excerpt

Norovirus (NoV) is the leading cause of acute gastroenteritis worldwide, causing over 200,000 deaths a year. NoV is nonenveloped, with a single-stranded RNA genome, and is primarily transmitted person to person. The viral RNA-dependent RNA polymerase (RdRp) is critical for the production of genomic and subgenomic RNA and is therefore a prime target for antiviral therapies. Using high-throughput screening, nearly...

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Identifiers

PMID: 24637690
DOI: 10.1128/AAC.02799-13
PMCID: PMC4068436

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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