Article
Nonnucleoside inhibitors of norovirus RNA polymerase: scaffolds for rational drug design.
Antimicrobial agents and chemotherapy - 1 Jun 2014
Eltahla Auda A, Lim Kun Lee, Eden John-Sebastian, Kelly Andrew G, Mackenzie Jason M, White Peter A
Abstract excerpt
Norovirus (NoV) is the leading cause of acute gastroenteritis worldwide, causing over 200,000 deaths a year. NoV is nonenveloped, with a single-stranded RNA genome, and is primarily transmitted person to person. The viral RNA-dependent RNA polymerase (RdRp) is critical for the production of genomic and subgenomic RNA and is therefore a prime target for antiviral therapies. Using high-throughput screening, nearly...
Topics
- Antiviral Agents
- Caliciviridae Infections
- Cell Line, Tumor
- Cell Survival
- Drug Design
- Gastroenteritis
- Genotype
- High-Throughput Screening Assays
- Humans
- Inhibitory Concentration 50