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Article

Targeting oncogenic TERT promoter variants by allele-specific epigenome editing.

Clinical epigenetics - 22 Nov 2023

Kouroukli Alexandra G, Rajaram Nivethika, Bashtrykov Pavel, Kretzmer Helene, Siebert Reiner, Jeltsch Albert, Bens Susanne

Abstract excerpt

BACKGROUND: Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. Silencing of such dominantly activated oncogenic alleles, thus, is a promising strategy to treat cancer. Recently, allele-specific epigenome editing (ASEE) has been described as a means to reduce transcription of genes in an allele-specific manner. In cancer, specificity to an...

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Share to Alleles
Share to DNA Methylation
Share to Epigenome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lung Neoplasms

Share to Nucleotides

Share to Promoter Regions, Genetic

Share to RNA, Guide, CRISPR-Cas Systems

Share to Telomerase

Source

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Identifiers

PMID: 37993930
DOI: 10.1186/s13148-023-01599-2
PMCID: PMC10666398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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