Article
Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody.
The Journal of biological chemistry - 9 Oct 2015
Jarantow Stephen W, Bushey Barbara S, Pardinas Jose R, Boakye Ken, Lacy Eilyn R, Sanders Renouard, Sepulveda Manuel A, Moores Sheri L, Chiu Mark L
Abstract excerpt
The efficacy of engaging multiple drug targets using bispecific antibodies (BsAbs) is affected by the relative cell-surface protein levels of the respective targets. In this work, the receptor density values were correlated to the in vitro activity of a BsAb (JNJ-61186372) targeting epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (c-MET). Simultaneous binding of the BsAb to both...
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