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Article

SUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer.

Cell reports - 26 Aug 2025

Xing Peiqi, Bak-Gordon Pedro, Xie Jindou, Zhang Jian, Liu Zhaoqi, Manley James L

Abstract excerpt

SF3B1 is the most frequently mutated splicing factor in cancer. Such mutations cause missplicing by promoting aberrant 3' splice site usage; however, how this occurs mechanistically remains controversial. To address this issue, we employed a computational screen of 600 splicing-related proteins to identify those whose reduced expression recapitulates mutant SF3B1-induced splicing dysregulation. Strikingly, our...

Topics

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Alternative Splicing
Carcinogenesis
SF3B1 gene
Mutation
Neoplasms
Phosphoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing Factors

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Open in PubMed Open full text

Identifiers

PMID: 40714635
DOI: 10.1016/j.celrep.2025.116075
PMCID: PMC12434867

Genes

SF3B1
SUGP1
AQR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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