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Article

(G)Patching up mis-splicing in cancer.

Trends in biochemical sciences - 1 Jul 2024

Cieśla Maciej, Bellodi Cristian

Abstract excerpt

Benbarche, Pineda, Galvis, et al. delineate an essential role for the G-patch motif-containing protein GPATCH8 in mis-splicing associated with cancer-driving mutations of the splicing factor SF3B1. GPATCH8 cooperates with SF3B1 mutants, affecting the splicing machinery. Targeting GPATCH8 reveals therapeutic opportunities for SF3B1 mutant cancers and other splicing-related diseases.

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Identifiers

PMID: 38762373
DOI: 10.1016/j.tibs.2024.05.001

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