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How epigenetic clocks tick: Unpacking the black box by deciphering biological pathways and transcriptomic signatures of accelerated aging

2026-03-16

Abstract excerpt

<title>Abstract</title> <p>Epigenetic clocks derived from DNA methylation robustly predict biological aging, health, and mortality, yet differ substantially in their predictive profiles. The biological processes underlying these differences remain poorly understood. Using data from 3,227 participants in the U.S. Health and Retirement Study, with contemporaneous DNA methylation and RNA-sequencing, we examined the...

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Literature Corpus work: 89e2ae27-47f4-5e13-839d-34bc9fc68df4
DOI: 10.21203/rs.3.rs-8844558/v1

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