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Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer

15 Nov 2023

Abstract excerpt

Aberrant DNA methylation has been implicated as a key driver of prostate cancer lineage plasticity and histologic transformation to neuroendocrine prostate cancer (NEPC). DNA methyltransferases (DNMTs) are highly expressed, and global DNA methylation is dysregulated in NEPC. We identified that deletion of DNMT genes decreases expression of neuroendocrine lineage markers and substantially reduced NEPC tumor...

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PMID: 37967200
DOI: 10.1126/scitranslmed.adf6732

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