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Identification and impact on Pseudomonas aeruginosa virulence of mutations conferring resistance to a phage cocktail for phage therapy.

Microbiology spectrum - 12 Dec 2023

Forti Francesca, Bertoli Claudia, Cafora Marco, Gilardi Sara, Pistocchi Anna, Briani Federica

Abstract excerpt

IMPORTANCE: In this work, we identified the putative receptors of 16 Pseudomonas phages and evaluated how resistance to phages recognizing different bacterial receptors may affect the virulence. Our findings are relevant for the implementation of phage therapy of Pseudomonas aeruginosa infections, which are difficult to treat with antibiotics. Overall, our results highlight the need to modify natural phages to...

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Identifiers

PMID: 37966242
DOI: 10.1128/spectrum.01477-23
PMCID: PMC10714927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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