Article
Emerging Phage Resistance in Pseudomonas aeruginosa PAO1 Is Accompanied by an Enhanced Heterogeneity and Reduced Virulence.
Viruses - 10 Jul 2021
Markwitz Pawel, Olszak Tomasz, Gula Grzegorz, Kowalska Magdalena, Arabski Michal, Drulis-Kawa Zuzanna
Abstract excerpt
Bacterial surface structures of a proteinic nature and glycoconjugates contribute to biofilm formation and provide shields to host defense mechanisms (e.g., the complement system and phagocytosis). A loss or alteration of these molecules, leading to phage resistance, could result in fewer virulent bacteria. In this study, we evaluate the biology and phenotype changes in Pseudomonas aeruginosa PAO1 phage-resistant...
Topics
- Anti-Bacterial Agents
- Bacteriophages
- Biofilms
- Drug Resistance, Microbial
- Humans
- Phage Therapy
- Phagocytosis
- Phenotype
- Pseudomonas Infections
- Pseudomonas Phages
- Pseudomonas aeruginosa
- Virulence
