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Bacterial Receptors but Not Anti-Phage Defense Mechanisms Determine Host Range for a Pair of <i>Pseudomonas aeruginosa</i> Lytic Phages

2024-05-01

Abstract excerpt

<h4>Summary</h4> Limited phage host range remains one of the obstacles to the widespread use of phage therapy against bacterial infections. Here, we perform a genome-wide association study (GWAS) using Pseudomonas aeruginosa clinical isolates collected from people with cystic fibrosis (pwCF) to identify bacterial genes associated with resistance or susceptibility to two lytic phages, OMKO1 and LPS-5, recently us...

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Identifiers and source

Literature Corpus work
4469a90a-6fbf-5e3d-b67b-79a366a04202
DOI
10.1101/2024.04.30.591980
Open publication

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Bacterial Receptors but Not Anti-Phage Defense Mechanisms Determine Host Range for a Pair of <i>Pseudomonas aeruginosa</i> Lytic PhagesDOI 10.1101/2024.04.30.591980
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