Article
Phage cocktails containing a dual-receptor Phikzvirus suppress resistance evolution in Pseudomonas aeruginosa.
Applied and environmental microbiology - 18 Feb 2026
Fujiki Jumpei, Tamamura Kohana, Nakamura Keisuke, Nakamura Tomohiro, Sakata Yoshiaki, Kimura Nana, Ono Sayaka, Kojima Nozomi, Inaba-Hasegawa Keiko, Sasaki Michihito, Usui Masaru, Iwasaki Tomohito, Ando Hiroki, Sawa Hirofumi, Iwano Hidetomo
Abstract excerpt
While phage therapy is one of the promising strategies against antimicrobial resistant infections by Pseudomonas aeruginosa, the rapid emergence of phage-resistant variants remains a significant barrier to its long-term clinical efficacy, reflecting the constant evolutionary arms race between phages and their hosts. Here, we first characterized ΦBrmt, a Phikzvirus phage previously isolated from an LPS-defective...
Topics
- Pseudomonas aeruginosa
- Pseudomonas Phages
- Mutation
- Fimbriae, Bacterial
- Receptors, Virus