Article
Pseudomonas aeruginosa PA5oct Jumbo Phage Impacts Planktonic and Biofilm Population and Reduces Its Host Virulence.
Viruses - 23 Nov 2019
Olszak Tomasz, Danis-Wlodarczyk Katarzyna, Arabski Michal, Gula Grzegorz, Maciejewska Barbara, Wasik Slawomir, Lood Cédric, Higgins Gerard, Harvey Brian J, Lavigne Rob, Drulis-Kawa Zuzanna
Abstract excerpt
The emergence of phage-resistant mutants is a key aspect of lytic phages-bacteria interaction and the main driver for the co-evolution between both organisms. Here, we analyze the impact of PA5oct jumbo phage treatment on planktonic/cell line associated and sessile P. aeruginosa population. Besides its broad-spectrum activity and efficient bacteria reduction in both airway surface liquid (ASL) model, and biofilm...
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