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Article

High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations

20 Nov 2018

Abstract excerpt

Brain and spinal arteriovenous malformations are congenital lesions causing intracranial haemorrhage or permanent disability especially in young people. We investigated whether the vast majority or all brain and spinal arteriovenous malformations are associated with detectable tumour-related somatic mutations. In a cohort of 31 patients (21 with brain and 10 with spinal arteriovenous malformations), tissue and...

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PMID: 30544177
DOI: 10.1093/brain/awy307

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