Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of stress granule formation is a vulnerability imposed by mutant p53.

Nature communications - 10 Mar 2025

Thoenen Elizabeth, Ranjan Atul, Parrales Alejandro, Nishikawa Shigeto, Dixon Dan A, Oka Sugako, Iwakuma Tomoo

Abstract excerpt

Missense mutations in the TP53 (p53) gene have been linked to malignant progression. However, our in-silico analyses reveal that hepatocellular carcinoma (HCC) patients with mutant p53 (mutp53) have better overall survival compared to those with p53-null (p53null) HCC, unlike other cancer types. Given the historical use of sorafenib (SOR) monotherapy for advanced HCC, we hypothesize that mutp53 increases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Hepatocellular
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to eIF-2 Kinase

Share to Endoplasmic Reticulum Stress

Share to Poly-ADP-Ribose Binding Proteins

Share to RNA Helicases

Share to Sorafenib

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 40064891
DOI: 10.1038/s41467-025-57539-6
PMCID: PMC11894096

Genes

G3BP1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of stress granule formation is a vulnerability imposed by mutant p53.PMID 40064891Read ↗

Battle Against Cancer: An Everlasting Saga of p53Semantic proximity Read ↗

Treating p53 Mutant Aggregation-Associated CancerSemantic proximity Read ↗

p53's Extended Reach: The Mutant p53 Secretome.Semantic proximity Read ↗

PERK-Olating Through Cancer: A Brew of Cellular DecisionsSemantic proximity Read ↗

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer ProgressionSemantic proximity Read ↗

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47Semantic proximity Read ↗

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept.Semantic proximity Read ↗

Anticancer Therapeutic Strategies Targeting p53 Aggregation.Semantic proximity Read ↗

Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome.Semantic proximity Read ↗

ELK1/NOL3/GRP78 axis regulates proliferation and stemness in TP53-mutant colon cancer by enhancing adaptive endoplasmic reticulum stress.Semantic proximity Read ↗

p53 protein aggregation promotes platinum resistance in ovarian cancer.Semantic proximity Read ↗

Suppression of HSF1 activity by wildtype p53 creates the driving force for p53 loss-of-heterozygosity, enabling mutant p53 stabilization and invasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.