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Article

Mutant p53-Mediated Tumor Secretome: Bridging Tumor Cells and Stromal Cells.

Genes - 17 Dec 2024

Qiu Lei, Ma Zelong, Wu Xiaoming

Abstract excerpt

The tumor secretome comprises the totality of protein factors secreted by various cell components within the tumor microenvironment, serving as the primary medium for signal transduction between tumor cells and between tumor cells and stromal cells. The deletion or mutation of the p53 gene leads to alterations in cellular secretion characteristics, contributing to the construction of the tumor microenvironment in...

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Identifiers

PMID: 39766882
DOI: 10.3390/genes15121615
PMCID: PMC11675497

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