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Article

Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma

24 Jul 2019

Abstract excerpt

BACKGROUND: Isocitrate dehydrogenase wild-type (WT) glioblastoma (GBM) accounts for 90% of all GBMs, yet only 27% of isocitrate dehydrogenase WT-GBMs have p53 mutations. However, the tumor surveillance function of WT-p53 in GBM is subverted by mechanisms that are not fully understood. METHODS: We investigated the proteolytic inactivation of WT-p53 by asparaginyl endopeptidase (AEP) and its effects on GBM...

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PMID: 31400201
DOI: 10.1093/jnci/djz155

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